6CSD

V308E mutant of cytochrome P450 2D6 complexed with prinomastat

Summary for 6CSD

• Entry DOI: 10.2210/pdb6csd/pdb
• Descriptor: Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Prinomastat, ... (6 entities in total)
• Functional Keywords: conformational change proximal surface distal surface substrate binding c-d loop, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 111223.30

Authors

Yang, Y.T.,Fujita, K.,Wang, P.F.,Im, S.C.,Pearl, N.M.,Meagher, J.,Stuckey, J.,Waskell, L. (deposition date: 2018-03-20, release date: 2019-03-27, Last modification date: 2023-10-04)

• Primary citation: Yang, Y.T.,Fujita, F.,Wang, P.F.,Im, S.C.,Pearl, N.M.,Meagher, J.,Stuckey, J.,Waskell, L.; Characteristic conformational changes on the distal and proximal surfaces of cytochrome P450 2D6 in response to substrate binding; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.391 Å)