6CSD
V308E mutant of cytochrome P450 2D6 complexed with prinomastat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cytochrome P450 2D6 | polymer | 479 | 53760.6 | 2 | UniProt (P10635) Pfam (PF00067) | Homo sapiens (Human) | CYPIID6,Cholesterol 25-hydroxylase,Cytochrome P450-DB1,Debrisoquine 4-hydroxylase |
| 2 | C, I (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, J (A, B) | Prinomastat | non-polymer | 423.5 | 2 | Chemie (PN0) PubChem (22058234) PubChem (466151) PubChem (54513250) | |||
| 4 | E, K (A, B) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 2 | Chemie (CPS) PubChem (16396400) PubChem (18397788) PubChem (177530666) PubChem (24883538) PubChem (457060) PubChem (44120060) PubChem (44450441) PubChem (50987450) PubChem (51028881) PubChem (51028882) PubChem (53393728) PubChem (3659871) PubChem (58528211) PubChem (53229977) PubChem (107670) PubChem (71774074) PubChem (9895216) PubChem (10371606) PubChem (90488808) PubChem (91746229) PubChem (91809267) PubChem (102565428) PubChem (122361936) PubChem (122362044) PubChem (131632459) PubChem (133645855) PubChem (137704711) PubChem (146159681) | |||
| 5 | F, G, H, L, M... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 6 | O, P (A, B) | water | water | 18.0 | 413 | Chemie (HOH) |
Sequence modifications
A, B: 34 - 497 (UniProt: P10635)
| PDB | External Database | Details |
|---|---|---|
| Met 23 | - | initiating methionine |
| Ala 24 | - | expression tag |
| Lys 25 | - | expression tag |
| Lys 26 | - | expression tag |
| Thr 27 | - | expression tag |
| Ser 28 | - | expression tag |
| Ser 29 | - | expression tag |
| Lys 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Lys 32 | - | expression tag |
| Leu 33 | - | expression tag |
| Glu 308 | Val 308 | engineered mutation |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 107521.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3702.2 | |
| All* | Total formula weight | 111223.3 |
