6CSD
V308E mutant of cytochrome P450 2D6 complexed with prinomastat
Summary for 6CSD
Entry DOI | 10.2210/pdb6csd/pdb |
Descriptor | Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Prinomastat, ... (6 entities in total) |
Functional Keywords | conformational change proximal surface distal surface substrate binding c-d loop, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 111223.30 |
Authors | Yang, Y.T.,Fujita, K.,Wang, P.F.,Im, S.C.,Pearl, N.M.,Meagher, J.,Stuckey, J.,Waskell, L. (deposition date: 2018-03-20, release date: 2019-03-27, Last modification date: 2023-10-04) |
Primary citation | Yang, Y.T.,Fujita, F.,Wang, P.F.,Im, S.C.,Pearl, N.M.,Meagher, J.,Stuckey, J.,Waskell, L. Characteristic conformational changes on the distal and proximal surfaces of cytochrome P450 2D6 in response to substrate binding To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.391 Å) |
Structure validation
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