6CR6

Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CH-CH3, beta, gamma dATP analogue

Summary for 6CR6

DescriptorTemplate Strand, Primer Strand, Downstream Primer Strand, ... (8 entities in total)
Functional Keywordsconformational change, enzyme mechanism, lfer, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight48263.37
Authors
Batra, V.K.,Wilson, S.H. (deposition date: 2018-03-16, release date: 2018-08-22)
Primary citation
Batra, V.K.,Oertell, K.,Beard, W.A.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H.
Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.
Biochemistry, 57:3934-3944, 2018
PubMed: 29874056 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.8b00418
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.097 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.29370.3%2.1%9.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution