6CQD

Crystal structure of HPK1 in complex with ATP analogue (AMPPNP)

Summary for 6CQD

• Entry DOI: 10.2210/pdb6cqd/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: protein kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 67498.21

Authors

Wu, P.,Lehoux, I.,Franke, Y.,Mortara, K.,Wang, W. (deposition date: 2018-03-14, release date: 2018-12-19, Last modification date: 2024-03-13)

• Primary citation: Wu, P.,Sneeringer, C.J.,Pitts, K.E.,Day, E.S.,Chan, B.K.,Wei, B.,Lehoux, I.,Mortara, K.,Li, H.,Wu, J.,Franke, Y.,Moffat, J.G.,Grogan, J.L.,Heffron, T.P.,Wang, W.; Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.; Structure, 27:125-133.e4, 2019; PubMed: 30503777; DOI: 10.1016/j.str.2018.10.025

Experimental method

X-RAY DIFFRACTION (2.12 Å)