6CPF

Structure of dephosphorylated Aurora A (122-403) bound to AMPPCP in an active conformation

Replaces:  4UTD

Summary for 6CPF

• Entry DOI: 10.2210/pdb6cpf/pdb
• Descriptor: Aurora kinase A, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: protein kinase, dfg-loop, transferase, cell cycle
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33520.27

Authors

Otten, R.,Zorba, A.,Padua, R.A.P.,Kern, D. (deposition date: 2018-03-13, release date: 2018-06-27, Last modification date: 2023-10-04)

• Primary citation: Pitsawong, W.,Buosi, V.,Otten, R.,Agafonov, R.V.,Zorba, A.,Kern, N.,Kutter, S.,Kern, G.,Padua, R.A.,Meniche, X.,Kern, D.; Dynamics of human protein kinase Aurora A linked to drug selectivity.; Elife, 7:-, 2018; PubMed: 29901437; DOI: 10.7554/eLife.36656

Experimental method

X-RAY DIFFRACTION (2.3 Å)