6CNU

Crystal Structure of JzTX-V

Summary for 6CNU

• Entry DOI: 10.2210/pdb6cnu/pdb
• Descriptor: JzTx-V(D), JzTx-V, BROMIDE ION, ... (6 entities in total)
• Functional Keywords: inhibitor cysteine knot, toxin
• Biological source: Chilobrachys guangxiensis (Chinese earth tiger tarantula); More
• Total number of polymer chains: 2
• Total formula weight: 7852.69

Authors

Min, X.,Wang, Z. (deposition date: 2018-03-09, release date: 2019-03-06, Last modification date: 2020-03-04)

• Primary citation: Wu, B.,Murray, J.K.,Andrews, K.L.,Sham, K.,Long, J.,Aral, J.,Ligutti, J.,Amagasu, S.,Liu, D.,Zou, A.,Min, X.,Wang, Z.,Ilch, C.P.,Kornecook, T.J.,Lin, M.J.,Be, X.,Miranda, L.P.,Moyer, B.D.,Biswas, K.; Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.; J. Med. Chem., 61:9500-9512, 2018; PubMed: 30346167; DOI: 10.1021/acs.jmedchem.8b00736

Experimental method

X-RAY DIFFRACTION (1.05 Å)