6CNH

Human PRPF4B in complex with Rebastinib

Summary for 6CNH

DescriptorSerine/threonine-protein kinase PRP4 homolog, 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase, inhibitor, dcc2036, structural genomics, structural genomics consortium, sgc, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight41821.23
Authors
Primary citation
Godoi, P.H.C.,Santiago, A.S.,Ramos, P.Z.,Silva, P.N.B.,Righetto, G.L.,Guimaraes, C.R.W.,Massirer, K.B.,Arruda, P.,Elkins, J.M.,Edwards, A.M.
Crystal structure of the human PRPF4B in complex with Rebastinib
To be Published,
Experimental method
X-RAY DIFFRACTION (2 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20810 3.3% 7.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution