6CMS

Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor

6CMS の概要

• エントリーDOI: 10.2210/pdb6cms/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 11, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine (3 entities in total)
• 機能のキーワード: protein tyrosine phosphatase, src homology domain 2, inactive state, active mutant, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61357.15

構造登録者

Padua, R.A.P.,Sun, Y.,Marko, I.,Pitsawong, W.,Kern, D. (登録日: 2018-03-06, 公開日: 2018-11-14, 最終更新日: 2023-10-04)

• 主引用文献: Padua, R.A.P.,Sun, Y.,Marko, I.,Pitsawong, W.,Stiller, J.B.,Otten, R.,Kern, D.; Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2.; Nat Commun, 9:4507-4507, 2018; PubMed: 30375376; DOI: 10.1038/s41467-018-06814-w

実験手法

X-RAY DIFFRACTION (2.68 Å)