6CMN

Co-Crystal Structure of HIV-1 TAR Bound to Lab-Evolved RRM TBP6.7

6CMN の概要

• エントリーDOI: 10.2210/pdb6cmn/pdb
• 分子名称: TAR-Binding Protein 6.7, Trans-Activation Response RNA Element (3 entities in total)
• 機能のキーワード: protein-rna complex, tar rna, lab-evolved protein, arginine fork, beta hairpin, major-groove readout, base triple, u1a, hiv-1, trans-activation, rna recognition motif, rrm, rna binding protein-rna complex, rna binding protein/rna
• 由来する生物種: Oryctolagus cuniculus (Rabbit); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22383.00

構造登録者

Belashov, I.A.,Wedekind, J.E. (登録日: 2018-03-05, 公開日: 2018-06-06, 最終更新日: 2023-10-04)

• 主引用文献: Belashov, I.A.,Crawford, D.W.,Cavender, C.E.,Dai, P.,Beardslee, P.C.,Mathews, D.H.,Pentelute, B.L.,McNaughton, B.R.,Wedekind, J.E.; Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription.; Nucleic Acids Res., 46:6401-6415, 2018; PubMed: 29961805; DOI: 10.1093/nar/gky529

実験手法

X-RAY DIFFRACTION (1.796 Å)