6CM4

Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone

Replaces:  6C38

Summary for 6CM4

• Entry DOI: 10.2210/pdb6cm4/pdb
• Descriptor: D(2) dopamine receptor, endolysin chimera, 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• Functional Keywords: gpcr, d2, dopamine receptor, antipsychotic, risperidone, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 50455.63

Authors

Wang, S.,Che, T.,Levit, A.,Shoichet, B.K.,Wacker, D.,Roth, B.L. (deposition date: 2018-03-02, release date: 2018-03-14, Last modification date: 2023-10-04)

• Primary citation: Wang, S.,Che, T.,Levit, A.,Shoichet, B.K.,Wacker, D.,Roth, B.L.; Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.; Nature, 555:269-273, 2018; PubMed: 29466326; DOI: 10.1038/nature25758

Experimental method

X-RAY DIFFRACTION (2.867 Å)