6CM4
Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone
Replaces: 6C38Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | D(2) dopamine receptor, endolysin chimera | polymer | 430 | 48879.4 | 1 | UniProt (P14416) UniProt (D9IEF7) Pfam (PF00001) Pfam (PF00959) UniProt (by SIFTS) (P00720) In PDB | Homo sapiens (Human) | Dopamine D2 receptor, Lysis protein, Lysozyme, Muramidase, Dopamine D2 receptor |
2 | A | 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one | non-polymer | 410.5 | 1 | Chemie (8NU) | |||
3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
4 | A | OLEIC ACID | non-polymer | 282.5 | 3 | Chemie (OLA) | |||
5 | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A: 35 - 222 (UniProt: P14416)
A: 1002 - 1161 (UniProt: D9IEF7)
A: 362 - 443 (UniProt: P14416)
PDB | External Database | Details |
---|---|---|
Ala 122 | Ile 122 | conflict |
PDB | External Database | Details |
---|---|---|
Thr 1054 | Cys 54 | conflict |
Ala 1097 | Cys 97 | conflict |
PDB | External Database | Details |
---|---|---|
Ala 375 | Leu 375 | conflict |
Ala 379 | Leu 379 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 48879.4 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1576.2 | |
All* | Total formula weight | 50455.6 |