6CM2
SAMHD1 HD domain bound to decitabine triphosphate
Summary for 6CM2
Entry DOI | 10.2210/pdb6cm2/pdb |
Descriptor | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 6-amino-3-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-3,4-dihydro-1,3,5-triazin-2(1H)-one, GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | samhd1, analogues, decitabine, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 244367.92 |
Authors | Oellerich, T.,Schneider, C.,Thomas, D.,Knecht, K.M.,Buzovetsky, O.,Kaderali, L.,Schliemann, C.,Bohnenberger, H.,Angenendt, L.,Hartmann, W.,Wardelmann, E.,Rothenburger, T.,Mohr, S.,Scheich, S.,Comoglio, F.,Wilke, A.,Strobel, P.,Serve, H.,Michaelis, M.,Ferreiros, N.,Geisslinger, G.,Xiong, Y.,Keppler, O.T.,Cinatl, J. (deposition date: 2018-03-02, release date: 2019-06-19, Last modification date: 2023-10-04) |
Primary citation | Oellerich, T.,Schneider, C.,Thomas, D.,Knecht, K.M.,Buzovetsky, O.,Kaderali, L.,Schliemann, C.,Bohnenberger, H.,Angenendt, L.,Hartmann, W.,Wardelmann, E.,Rothenburger, T.,Mohr, S.,Scheich, S.,Comoglio, F.,Wilke, A.,Strobel, P.,Serve, H.,Michaelis, M.,Ferreiros, N.,Geisslinger, G.,Xiong, Y.,Keppler, O.T.,Cinatl Jr., J. Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML. Nat Commun, 10:3475-3475, 2019 Cited by PubMed: 31375673DOI: 10.1038/s41467-019-11413-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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