6CLX

Crystal structure of TnmH in complex with SAM

Summary for 6CLX

Entry DOI	10.2210/pdb6clx/pdb
Descriptor	O-methyltransferase, S-ADENOSYLMETHIONINE (3 entities in total)
Functional Keywords	methyltransferase, biosynthetic protein
Biological source	Streptomyces sp. CB03234
Total number of polymer chains	2
Total formula weight	78774.73
Authors	Chang, C.Y.,Annaval, T.,Adhikari, A.,Yan, X.,Shen, B. (deposition date: 2018-03-02, release date: 2019-03-06, Last modification date: 2023-11-15)
Primary citation	Adhikari, A.,Teijaro, C.N.,Yan, X.,Chang, C.Y.,Gui, C.,Liu, Y.C.,Crnovcic, I.,Yang, D.,Annaval, T.,Rader, C.,Shen, B. Characterization of TnmH as anO-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates. J.Med.Chem., 63:8432-8441, 2020 Cited by PubMed: 32658465 DOI: 10.1021/acs.jmedchem.0c00799 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.73 Å)

Structure validation