6CKC

Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity

6CKC の概要

• エントリーDOI: 10.2210/pdb6ckc/pdb
• 分子名称: Protein arginine N-methyltransferase 5, Methylosome protein 50, 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 111506.93

構造登録者

Antonysamy, S. (登録日: 2018-02-27, 公開日: 2018-05-16, 最終更新日: 2024-03-13)

• 主引用文献: Bonday, Z.Q.,Cortez, G.S.,Grogan, M.J.,Antonysamy, S.,Weichert, K.,Bocchinfuso, W.P.,Li, F.,Kennedy, S.,Li, B.,Mader, M.M.,Arrowsmith, C.H.,Brown, P.J.,Eram, M.S.,Szewczyk, M.M.,Barsyte-Lovejoy, D.,Vedadi, M.,Guccione, E.,Campbell, R.M.; LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.; ACS Med Chem Lett, 9:612-617, 2018; PubMed: 30034588; DOI: 10.1021/acsmedchemlett.8b00014

実験手法

X-RAY DIFFRACTION (2.8 Å)