6CJX

Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 2)

6CJX の概要

• エントリーDOI: 10.2210/pdb6cjx/pdb
• 分子名称: Fc fragment of human IgG1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: immunoglobulin, igg1, immune system, immunoglobulin-like beta sandwich, fc fragment, lala mutation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51225.28

構造登録者

Van, V.,Tolbert, W.D.,Pazgier, M. (登録日: 2018-02-27, 公開日: 2019-03-06, 最終更新日: 2023-10-04)

• 主引用文献: Orlandi, C.,Deredge, D.,Ray, K.,Gohain, N.,Tolbert, W.,DeVico, A.L.,Wintrode, P.,Pazgier, M.,Lewis, G.K.; Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fc gamma Receptor Binding.; Structure, 2020; PubMed: 32209433; DOI: 10.1016/j.str.2020.03.001

実験手法

X-RAY DIFFRACTION (2.44 Å)