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6CJS

Candida albicans Hsp90 nucleotide binding domain in complex with AUY922

Summary for 6CJS
Entry DOI10.2210/pdb6cjs/pdb
Related6CJI 6CJJ 6CJL 6CJP 6CJR
DescriptorHeat shock protein 90 homolog, 5-[2,4-DIHYDROXY-5-(1-METHYLETHYL)PHENYL]-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordshsp90. atpase, chaperone
Biological sourceCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Total number of polymer chains1
Total formula weight26736.25
Authors
Kirkpatrick, M.G.,Pizarro, J.C. (deposition date: 2018-02-26, release date: 2019-01-30, Last modification date: 2023-10-04)
Primary citationWhitesell, L.,Robbins, N.,Huang, D.S.,McLellan, C.A.,Shekhar-Guturja, T.,LeBlanc, E.V.,Nation, C.S.,Hui, R.,Hutchinson, A.,Collins, C.,Chatterjee, S.,Trilles, R.,Xie, J.L.,Krysan, D.J.,Lindquist, S.,Porco Jr., J.A.,Tatu, U.,Brown, L.E.,Pizarro, J.,Cowen, L.E.
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Nat Commun, 10:402-402, 2019
Cited by
PubMed: 30679438
DOI: 10.1038/s41467-018-08248-w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

221051

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