6CJF

Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43

6CJF の概要

• エントリーDOI: 10.2210/pdb6cjf/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, oxidoreductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84465.90

構造登録者

Petrunak, E.M.,Stuckey, J.A. (登録日: 2018-02-26, 公開日: 2018-05-23, 最終更新日: 2023-10-04)

• 主引用文献: Madak, J.T.,Cuthbertson, C.R.,Miyata, Y.,Tamura, S.,Petrunak, E.M.,Stuckey, J.A.,Han, Y.,He, M.,Sun, D.,Showalter, H.D.,Neamati, N.; Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.; J. Med. Chem., 61:5162-5186, 2018; PubMed: 29727569; DOI: 10.1021/acs.jmedchem.7b01862

実験手法

X-RAY DIFFRACTION (1.63 Å)