6CIZ
Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 nitrile
Summary for 6CIZ
Entry DOI | 10.2210/pdb6ciz/pdb |
Descriptor | Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, 6-cyano-17-(3-pyridyl)-androst-5,16-dien-3-ol, ... (4 entities in total) |
Functional Keywords | cytochrome p450, p450, cyp17a1, p450c17, p450 17a1, monooxygenase, 17a-hydroxylase, 17, 20-lyase, heme protein, cytochrome p450 oxidoreductase, membrane, microsome, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 226924.59 |
Authors | Scott, E.E.,Fehl, C. (deposition date: 2018-02-25, release date: 2018-06-06, Last modification date: 2023-10-04) |
Primary citation | Fehl, C.,Vogt, C.D.,Yadav, R.,Li, K.,Scott, E.E.,Aube, J. Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2. J. Med. Chem., 61:4946-4960, 2018 Cited by PubMed: 29792703DOI: 10.1021/acs.jmedchem.8b00419 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.601 Å) |
Structure validation
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