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6CID

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with N-(1-(Piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide

Summary for 6CID
Entry DOI10.2210/pdb6cid/pdb
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsnitric oxide synthase inhibitor complex heme enzyme, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight100182.94
Authors
Li, H.,Poulos, T.L. (deposition date: 2018-02-23, release date: 2018-10-31, Last modification date: 2023-10-04)
Primary citationLi, H.,Evenson, R.J.,Chreifi, G.,Silverman, R.B.,Poulos, T.L.
Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides.
Biochemistry, 57:6319-6325, 2018
Cited by
PubMed: 30335983
DOI: 10.1021/acs.biochem.8b00895
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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