6CGW

Solution NMR structure of JzTx-V, a Nav 1.7 inhibitory peptide

Summary for 6CGW

• Entry DOI: 10.2210/pdb6cgw/pdb
• NMR Information: BMRB: 30411
• Descriptor: Beta/kappa-theraphotoxin-Cg2a (1 entity in total)
• Functional Keywords: fractionated tarantula venom, nav 1.7 inhibitor, toxin
• Biological source: Chilobrachys guangxiensis (Chinese earth tiger tarantula)
• Cellular location: Secreted : Q2PAY4
• Total number of polymer chains: 1
• Total formula weight: 3617.36

Authors

Jordan, J.B.,Andrews, K. (deposition date: 2018-02-21, release date: 2018-05-02, Last modification date: 2023-11-15)

• Primary citation: Moyer, B.D.,Murray, J.K.,Ligutti, J.,Andrews, K.,Favreau, P.,Jordan, J.B.,Lee, J.H.,Liu, D.,Long, J.,Sham, K.,Shi, L.,Stocklin, R.,Wu, B.,Yin, R.,Yu, V.,Zou, A.,Biswas, K.,Miranda, L.P.; Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.; PLoS ONE, 13:e0196791-e0196791, 2018; PubMed: 29723257; DOI: 10.1371/journal.pone.0196791

Experimental method

SOLUTION NMR