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6CGE

Crystal structure of human 17beta-HSD type 1 in ternary complex with PBRM and NADP+

Summary for 6CGE
Entry DOI10.2210/pdb6cge/pdb
DescriptorEstradiol 17-beta-dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-{[(14beta,16alpha,17alpha)-3-(2-bromoethyl)-17-hydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide, ... (4 entities in total)
Functional Keywordsinhibitor, complex, hydroxysteroid dehydrogenase, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight72457.77
Authors
Li, T.,Lin, S.X. (deposition date: 2018-02-20, release date: 2019-01-16, Last modification date: 2023-10-04)
Primary citationLi, T.,Maltais, R.,Poirier, D.,Lin, S.X.
Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide.
J Phys Chem Lett, 9:5275-5280, 2018
Cited by
PubMed: 30148957
DOI: 10.1021/acs.jpclett.8b02225
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

数据于2024-03-27公开中

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