6CGD
Aminoglycoside Phosphotransferase (2'')-Ia in complex with GMPPNP, Magnesium, and Amikacin
Summary for 6CGD
Entry DOI | 10.2210/pdb6cgd/pdb |
Related | 6C5U 6CAV 6CEY |
Descriptor | Bifunctional AAC/APH, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, ... (6 entities in total) |
Functional Keywords | kinase, antibiotic, aminoglycoside, resistance, transferase, transferase-antibiotic complex |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 4 |
Total formula weight | 147353.59 |
Authors | Caldwell, S.J.,Berghuis, A.M. (deposition date: 2018-02-20, release date: 2018-04-11, Last modification date: 2023-10-04) |
Primary citation | Caldwell, S.J.,Berghuis, A.M. Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia. Antimicrob. Agents Chemother., 62:-, 2018 Cited by PubMed: 29661878DOI: 10.1128/AAC.00202-18 PDB entries with the same primary citation |
Experimental method |
Structure validation
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