6CGC

Crystal structure of human 17beta-HSD type 1 in ternary complex with 2-MeO-CC-156 and NADP+

Summary for 6CGC

• Entry DOI: 10.2210/pdb6cgc/pdb
• Descriptor: Estradiol 17-beta-dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-{[(9beta,14beta,16alpha,17alpha)-3,17-dihydroxy-2-methoxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, hydroxysteroid dehydrogenase, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 72335.92

Authors

Li, T.,Lin, S.X. (deposition date: 2018-02-19, release date: 2019-01-16, Last modification date: 2023-10-04)

• Primary citation: Li, T.,Maltais, R.,Poirier, D.,Lin, S.X.; Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide.; J Phys Chem Lett, 9:5275-5280, 2018; PubMed: 30148957; DOI: 10.1021/acs.jpclett.8b02225

Experimental method

X-RAY DIFFRACTION (2.1 Å)