6CG2
Crystal Structure of KDM4A with Compound 8
Summary for 6CG2
Entry DOI | 10.2210/pdb6cg2/pdb |
Descriptor | Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | kdm4a, small molecule inhibitor, demethylase, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : O75164 |
Total number of polymer chains | 4 |
Total formula weight | 164667.24 |
Authors | Hosfield, D.J.,Nie, Z. (deposition date: 2018-02-19, release date: 2018-04-18, Last modification date: 2023-10-04) |
Primary citation | Nie, Z.,Shi, L.,Lai, C.,O'Connell, S.M.,Xu, J.,Stansfield, R.K.,Hosfield, D.J.,Veal, J.M.,Stafford, J.A. Structure-based design and discovery of potent and selective KDM5 inhibitors. Bioorg. Med. Chem. Lett., 28:1490-1494, 2018 Cited by PubMed: 29627262DOI: 10.1016/j.bmcl.2018.03.083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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