6CG2

Crystal Structure of KDM4A with Compound 8

Summary for 6CG2

Entry DOI	10.2210/pdb6cg2/pdb
Descriptor	Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (5 entities in total)
Functional Keywords	kdm4a, small molecule inhibitor, demethylase, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : O75164
Total number of polymer chains	4
Total formula weight	164667.24
Authors	Hosfield, D.J.,Nie, Z. (deposition date: 2018-02-19, release date: 2018-04-18, Last modification date: 2023-10-04)
Primary citation	Nie, Z.,Shi, L.,Lai, C.,O'Connell, S.M.,Xu, J.,Stansfield, R.K.,Hosfield, D.J.,Veal, J.M.,Stafford, J.A. Structure-based design and discovery of potent and selective KDM5 inhibitors. Bioorg. Med. Chem. Lett., 28:1490-1494, 2018 Cited by PubMed: 29627262 DOI: 10.1016/j.bmcl.2018.03.083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.34 Å)

Structure validation