6CFD

ADEP4 bound to E. faecium ClpP

Summary for 6CFD

Entry DOI	10.2210/pdb6cfd/pdb
Descriptor	ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL, N-[(6aS,12S,15aS,17R,21R,23aS)-17,21-dimethyl-6,11,15,20,23-pentaoxooctadecahydro-2H,6H,11H,15H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13]oxatetraazacyclohexadecin-12-yl]-3,5-difluoro-Nalpha-[(2E)-hept-2-enoyl]-L-phenylalaninamide, ... (4 entities in total)
Functional Keywords	clpp, adep4, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Enterococcus faecium (Streptococcus faecium)
Total number of polymer chains	14
Total formula weight	336298.86
Authors	Lee, R.E.,Griffith, E.C. (deposition date: 2018-02-14, release date: 2018-05-16, Last modification date: 2023-10-04)
Primary citation	Brown Gandt, A.,Griffith, E.C.,Lister, I.M.,Billings, L.L.,Han, A.,Tangallapally, R.,Zhao, Y.,Singh, A.P.,Lee, R.E.,LaFleur, M.D. In VivoandIn VitroEffects of a ClpP-Activating Antibiotic against Vancomycin-Resistant Enterococci. Antimicrob. Agents Chemother., 62:-, 2018 Cited by PubMed: 29784838 DOI: 10.1128/AAC.00424-18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.57 Å)

Structure validation