6CFD

ADEP4 bound to E. faecium ClpP

6CFD の概要

• エントリーDOI: 10.2210/pdb6cfd/pdb
• 分子名称: ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL, N-[(6aS,12S,15aS,17R,21R,23aS)-17,21-dimethyl-6,11,15,20,23-pentaoxooctadecahydro-2H,6H,11H,15H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13]oxatetraazacyclohexadecin-12-yl]-3,5-difluoro-Nalpha-[(2E)-hept-2-enoyl]-L-phenylalaninamide, ... (4 entities in total)
• 機能のキーワード: clpp, adep4, hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Enterococcus faecium (Streptococcus faecium)
• タンパク質・核酸の鎖数: 14
• 化学式量合計: 336298.86

構造登録者

Lee, R.E.,Griffith, E.C. (登録日: 2018-02-14, 公開日: 2018-05-16, 最終更新日: 2023-10-04)

• 主引用文献: Brown Gandt, A.,Griffith, E.C.,Lister, I.M.,Billings, L.L.,Han, A.,Tangallapally, R.,Zhao, Y.,Singh, A.P.,Lee, R.E.,LaFleur, M.D.; In VivoandIn VitroEffects of a ClpP-Activating Antibiotic against Vancomycin-Resistant Enterococci.; Antimicrob. Agents Chemother., 62:-, 2018; PubMed: 29784838; DOI: 10.1128/AAC.00424-18

実験手法

X-RAY DIFFRACTION (2.57 Å)