6CEN

Crystal Structure of WHSC1L1 in Complex with Inhibitor PEP21

Summary for 6CEN

• Entry DOI: 10.2210/pdb6cen/pdb
• Descriptor: Histone-lysine N-methyltransferase NSD3, ACE-GLY-VAL-NLE-ARG-ILE-NH2, S-ADENOSYLMETHIONINE, ... (5 entities in total)
• Functional Keywords: histone-lysine n-methyltransferase nsd3, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q9BZ95
• Total number of polymer chains: 2
• Total formula weight: 27112.05

Authors

Boriack-Sjodin, P.A.,Swinger, K.,Farrow, N.A. (deposition date: 2018-02-12, release date: 2018-05-09, Last modification date: 2018-05-23)

• Primary citation: Morrison, M.J.,Boriack-Sjodin, P.A.,Swinger, K.K.,Wigle, T.J.,Sadalge, D.,Kuntz, K.W.,Scott, M.P.,Janzen, W.P.,Chesworth, R.,Duncan, K.W.,Harvey, D.M.,Lampe, J.W.,Mitchell, L.H.,Copeland, R.A.; Identification of a peptide inhibitor for the histone methyltransferase WHSC1.; PLoS ONE, 13:e0197082-e0197082, 2018; PubMed: 29742153; DOI: 10.1371/journal.pone.0197082

Experimental method

X-RAY DIFFRACTION (1.61 Å)