6CEH

Design, Synthesis, X-ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology

Summary for 6CEH

Entry DOI	10.2210/pdb6ceh/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 4-[(prop-2-en-1-yl)selanyl]benzene-1-sulfonamide, ... (6 entities in total)
Functional Keywords	carbonic anhydrase inhibitors, diabetic pathology, organoselenium, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	30059.92
Authors	Peat, T.S.,Angeli, A.,di Cesare Mannelli, L.,Trallori, E.,Ghelardini, C.,Carta, F.,Supuran, C.T. (deposition date: 2018-02-11, release date: 2018-05-23, Last modification date: 2023-10-04)
Primary citation	Angeli, A.,di Cesare Mannelli, L.,Trallori, E.,Peat, T.S.,Ghelardini, C.,Carta, F.,Supuran, C.T. Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology. ACS Med Chem Lett, 9:462-467, 2018 Cited by PubMed: 29795760 DOI: 10.1021/acsmedchemlett.8b00076 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation