Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom

Summary for 6CE0

DescriptorEnvelope glycoprotein gp160, 35O22 Heavy chain, 35O22 Light chain, ... (9 entities in total)
Functional Keywordshiv-1 gp140, uncleaved prefusion-optimized (ufo), immune system, viral-protein complex, viral envelope trimer, broadly neutralizing antibody, viral protein, viral protein-immune system complex, viral protein/immune system
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains6
Total molecular weight177370.19
Kumar, S.,Sarkar, A.,Wilson, I.A. (deposition date: 2018-02-09, release date: 2018-12-05)
Primary citation
He, L.,Kumar, S.,Allen, J.D.,Huang, D.,Lin, X.,Mann, C.J.,Saye-Francisco, K.L.,Copps, J.,Sarkar, A.,Blizard, G.S.,Ozorowski, G.,Sok, D.,Crispin, M.,Ward, A.B.,Nemazee, D.,Burton, D.R.,Wilson, I.A.,Zhu, J.
HIV-1 vaccine design through minimizing envelope metastability.
Sci Adv, 4:eaau6769-eaau6769, 2018
PubMed: 30474059 (PDB entries with the same primary citation)
DOI: 10.1126/sciadv.aau6769
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.34210 0.4% 2.2% 6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution