6CE0

Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom

Summary for 6CE0

• Entry DOI: 10.2210/pdb6ce0/pdb
• Descriptor: Envelope glycoprotein gp160, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• Functional Keywords: hiv-1 gp140, uncleaved prefusion-optimized (ufo), immune system, viral-protein complex, viral envelope trimer, broadly neutralizing antibody, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 176937.82

Authors

Kumar, S.,Sarkar, A.,Wilson, I.A. (deposition date: 2018-02-09, release date: 2018-12-05, Last modification date: 2023-10-04)

• Primary citation: He, L.,Kumar, S.,Allen, J.D.,Huang, D.,Lin, X.,Mann, C.J.,Saye-Francisco, K.L.,Copps, J.,Sarkar, A.,Blizard, G.S.,Ozorowski, G.,Sok, D.,Crispin, M.,Ward, A.B.,Nemazee, D.,Burton, D.R.,Wilson, I.A.,Zhu, J.; HIV-1 vaccine design through minimizing envelope metastability.; Sci Adv, 4:eaau6769-eaau6769, 2018; PubMed: 30474059; DOI: 10.1126/sciadv.aau6769

Experimental method

X-RAY DIFFRACTION (4.602 Å)