6CCY
Crystal structure of Akt1 in complex with a selective inhibitor
Summary for 6CCY
Entry DOI | 10.2210/pdb6ccy/pdb |
Descriptor | RAC-alpha serine/threonine-protein kinase,PIFtide, (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one (3 entities in total) |
Functional Keywords | kinase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : Q16513 |
Total number of polymer chains | 1 |
Total formula weight | 40530.12 |
Authors | |
Primary citation | Parthasarathy, S.,Henry, K.,Pei, H.,Clayton, J.,Rempala, M.,Johns, D.,De Frutos, O.,Garcia, P.,Mateos, C.,Pleite, S.,Wang, Y.,Stout, S.,Condon, B.,Ashok, S.,Lu, Z.,Ehlhardt, W.,Raub, T.,Lai, M.,Geeganage, S.,Burkholder, T.P. Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT. Bioorg. Med. Chem. Lett., 28:1887-1891, 2018 Cited by PubMed: 29655979DOI: 10.1016/j.bmcl.2018.03.092 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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