6CCY

Crystal structure of Akt1 in complex with a selective inhibitor

6CCY の概要

• エントリーDOI: 10.2210/pdb6ccy/pdb
• 分子名称: RAC-alpha serine/threonine-protein kinase,PIFtide, (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one (3 entities in total)
• 機能のキーワード: kinase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm : Q16513
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40530.12

構造登録者

Wang, Y.,Stout, S. (登録日: 2018-02-07, 公開日: 2018-05-02, 最終更新日: 2018-05-16)

• 主引用文献: Parthasarathy, S.,Henry, K.,Pei, H.,Clayton, J.,Rempala, M.,Johns, D.,De Frutos, O.,Garcia, P.,Mateos, C.,Pleite, S.,Wang, Y.,Stout, S.,Condon, B.,Ashok, S.,Lu, Z.,Ehlhardt, W.,Raub, T.,Lai, M.,Geeganage, S.,Burkholder, T.P.; Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.; Bioorg. Med. Chem. Lett., 28:1887-1891, 2018; PubMed: 29655979; DOI: 10.1016/j.bmcl.2018.03.092

実験手法

X-RAY DIFFRACTION (2.18 Å)