6CCE

Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Kanglemycin A

Summary for 6CCE

Entry DOI	10.2210/pdb6cce/pdb
Descriptor	RNA polymerase-binding protein RbpA, SULFATE ION, ZINC ION, ... (14 entities in total)
Functional Keywords	rna polymerase antibiotic complex inhibitor tuberculosis, transcription, transcription-antibiotic complex, transcription-dna-antibiotic complex, transcription/dna/antibiotic
Biological source	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) More
Total number of polymer chains	9
Total formula weight	448861.88
Authors	Lilic, M.,Darst, S.A.,Campbell, E.A. (deposition date: 2018-02-07, release date: 2018-08-15, Last modification date: 2023-10-04)
Primary citation	Peek, J.,Lilic, M.,Montiel, D.,Milshteyn, A.,Woodworth, I.,Biggins, J.B.,Ternei, M.A.,Calle, P.Y.,Danziger, M.,Warrier, T.,Saito, K.,Braffman, N.,Fay, A.,Glickman, M.S.,Darst, S.A.,Campbell, E.A.,Brady, S.F. Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9:4147-4147, 2018 Cited by PubMed: 30297823 DOI: 10.1038/s41467-018-06587-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05 Å)

Structure validation