6CBM

x-ray structure of NeoB from streptomyces fradiae in complex with PLP and neomycin (as the external aldimine) at pH 9

6CBM の概要

• エントリーDOI: 10.2210/pdb6cbm/pdb
• 分子名称: Neamine transaminase NeoN, (1R,2R,3S,4R,6S)-4,6-diamino-2-[(3-O-{2-amino-2,6-dideoxy-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-alpha-D-glucopyranosyl}-beta-D-ribofuranosyl)oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: neomycin, aminotransferase, transferase
• 由来する生物種: Streptomyces fradiae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96216.54

構造登録者

Thoden, J.B.,Dow, G.T.,Holden, H.M. (登録日: 2018-02-03, 公開日: 2018-02-21, 最終更新日: 2023-10-04)

• 主引用文献: Dow, G.T.,Thoden, J.B.,Holden, H.M.; The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin.; Protein Sci., 27:945-956, 2018; PubMed: 29516565; DOI: 10.1002/pro.3400

実験手法

X-RAY DIFFRACTION (1.65 Å)