6CAE

Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution

これはPDB形式変換不可エントリーです。

6CAE の概要

• エントリーDOI: 10.2210/pdb6cae/pdb
• 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
• 機能のキーワード: noso-95179, odilorhabdin, antibiotic, inhibitor, ribosome, 70s, ribosome structure, inhibition of translation, decoding center, ribosome-inhibitor complex, ribosome/inhibitor
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 115
• 化学式量合計: 4576003.21

構造登録者

Pantel, L.,Florin, T.,Dobosz-Bartoszek, M.,Racine, E.,Sarciaux, M.,Serri, M.,Houard, J.,Campagne, J.M.,Marcia de Figueiredo, R.,Midrier, C.,Gaudriault, S.,Givaudan, A.,Lanois, A.,Forst, S.,Aumelas, A.,Cotteaux-Lautard, C.,Bolla, J.M.,Vingsbo Lundberg, C.,Huseby, D.,Hughes, D.,Villain-Guillot, P.,Mankin, A.S.,Polikanov, Y.S.,Gualtieri, M. (登録日: 2018-01-30, 公開日: 2018-04-18, 最終更新日: 2023-11-15)

• 主引用文献: Pantel, L.,Florin, T.,Dobosz-Bartoszek, M.,Racine, E.,Sarciaux, M.,Serri, M.,Houard, J.,Campagne, J.M.,de Figueiredo, R.M.,Midrier, C.,Gaudriault, S.,Givaudan, A.,Lanois, A.,Forst, S.,Aumelas, A.,Cotteaux-Lautard, C.,Bolla, J.M.,Vingsbo Lundberg, C.,Huseby, D.L.,Hughes, D.,Villain-Guillot, P.,Mankin, A.S.,Polikanov, Y.S.,Gualtieri, M.; Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.; Mol. Cell, 70:83-94.e7, 2018; PubMed: 29625040; DOI: 10.1016/j.molcel.2018.03.001

実験手法

X-RAY DIFFRACTION (2.6 Å)