6CAD
Crystal structure of RAF kinase domain bound to the inhibitor 2a
Summary for 6CAD
Entry DOI | 10.2210/pdb6cad/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, 1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | braf inhibitors, signaling protein |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 65444.81 |
Authors | Maisonneuve, P.,Kurinov, I.,Assadieskandar, A.,Yu, C.,Liu, X.,Chen, Y.-C.,Prakash, G.K.S.,Zhang, C.,SIcheri, F. (deposition date: 2018-01-30, release date: 2018-02-21, Last modification date: 2023-10-04) |
Primary citation | Assadieskandar, A.,Yu, C.,Maisonneuve, P.,Liu, X.,Chen, Y.C.,Prakash, G.K.S.,Kurinov, I.,Sicheri, F.,Zhang, C. Effects of rigidity on the selectivity of protein kinase inhibitors. Eur J Med Chem, 146:519-528, 2018 Cited by PubMed: 29407977DOI: 10.1016/j.ejmech.2018.01.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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