6C9H

non-phosphorylated AMP-activated protein kinase bound to pharmacological activator R734

Summary for 6C9H

Descriptor5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total)
Functional Keywordsampk, activator, r734, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight119818.33
Authors
Yan, Y.,Zhou, X.E.,Novick, S.,Shaw, S.J.,Li, Y.,Hitoshi, Y.,Brunzelle, J.S.,Griffin, P.R.,Xu, H.E.,Melcher, K. (deposition date: 2018-01-26, release date: 2018-11-28, Last modification date: 2019-01-30)
Primary citation
Yan, Y.,Zhou, X.E.,Novick, S.J.,Shaw, S.J.,Li, Y.,Brunzelle, J.S.,Hitoshi, Y.,Griffin, P.R.,Xu, H.E.,Melcher, K.
Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294:953-967, 2019
PubMed: 30478170 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.004883
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.65 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24370 0.2% 9.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution