6C9H
non-phosphorylated AMP-activated protein kinase bound to pharmacological activator R734
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 494 | 57165.6 | 1 | UniProt (Q13131) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) | Homo sapiens (Human) | AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1 |
| 2 | B (B) | 5'-AMP-activated protein kinase subunit beta-1 | polymer | 204 | 23071.3 | 1 | UniProt (Q9Y478) Pfam (PF16561) Pfam (PF04739) | Homo sapiens (Human) | AMPKb |
| 3 | C (C) | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 331 | 37626.3 | 1 | UniProt (P54619) Pfam (PF00571) | Homo sapiens (Human) | AMPKg |
| 4 | D (A) | 5-{[6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yl]oxy}-N-hydroxy-2-methylbenzamide | non-polymer | 446.9 | 1 | Chemie (R34) | |||
| 5 | E (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) PubChem (5279) PubChem (71203703) PubChem (42610657) PubChem (44259) PubChem (44299148) PubChem (49831000) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (68262703) PubChem (68306294) PubChem (451705) PubChem (73953205) PubChem (86306248) PubChem (358479) PubChem (5280487) PubChem (5459111) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (6419748) PubChem (9804568) PubChem (122130844) PubChem (12046017) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 6 | F, G, H (C) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 3 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 7 | I, J, K (A, B, C) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A: 13 - 471 (UniProt: Q13131)
A: 526 - 550 (UniProt: Q13131)
B: 68 - 270 (UniProt: Q9Y478)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | expression tag |
| Gly 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ser 12 | - | expression tag |
B: 68 - 270 (UniProt: Q9Y478)
| PDB | External Database | Details |
|---|---|---|
| Met 67 | - | expression tag |
| Asp 108 | Ser 108 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 117863.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1955.1 | |
| All* | Total formula weight | 119818.3 |
