6C9G

AMP-activated protein kinase bound to pharmacological activator R739

6C9G の概要

• エントリーDOI: 10.2210/pdb6c9g/pdb
• 関連するPDBエントリー: 6C9F
• 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total)
• 機能のキーワード: ampk, activator, crystal, r739, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 119937.34

構造登録者

Yan, Y.,Zhou, X.E.,Novick, S.,Shaw, S.J.,Li, Y.,Hitoshi, Y.,Brunzelle, J.S.,Griffin, P.R.,Xu, H.E.,Melcher, K. (登録日: 2018-01-26, 公開日: 2018-11-28, 最終更新日: 2023-10-04)

• 主引用文献: Yan, Y.,Zhou, X.E.,Novick, S.J.,Shaw, S.J.,Li, Y.,Brunzelle, J.S.,Hitoshi, Y.,Griffin, P.R.,Xu, H.E.,Melcher, K.; Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.; J. Biol. Chem., 294:953-967, 2019; PubMed: 30478170; DOI: 10.1074/jbc.RA118.004883

実験手法

X-RAY DIFFRACTION (2.7 Å)