6C89

NDM-1 Beta-Lactamase Exhibits Differential Active Site Sequence Requirements for the Hydrolysis of Penicillin versus Carbapenem Antibiotics

Summary for 6C89

• Entry DOI: 10.2210/pdb6c89/pdb
• Descriptor: Beta-lactamase, ZINC ION, 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: ndm-1; beta-lactamase; deep sequencing; antibiotic resistance; beta-lactams, antimicrobial protein
• Biological source: Escherichia coli
• Total number of polymer chains: 4
• Total formula weight: 98758.36

Authors

Palzkill, T.,Sun, Z.,Sankaran, B. (deposition date: 2018-01-24, release date: 2018-12-12, Last modification date: 2023-10-04)

• Primary citation: Sun, Z.,Hu, L.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T.; Differential active site requirements for NDM-1 beta-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics.; Nat Commun, 9:4524-4524, 2018; PubMed: 30375382; DOI: 10.1038/s41467-018-06839-1

Experimental method

X-RAY DIFFRACTION (1.75006148726 Å)