6C7W

Carbonic anhydrase 2 in complex with [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE inhibitor

Summary for 6C7W

• Entry DOI: 10.2210/pdb6c7w/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE, ... (5 entities in total)
• Functional Keywords: human carbonic anhydrase ii; inhibitor; natural product, lyase, lyase-inhibitor complex, lyase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 29723.78

Authors

Peat, T.S.,Mujumdar, P.,Poulsen, S.A. (deposition date: 2018-01-23, release date: 2018-05-23, Last modification date: 2023-10-04)

• Primary citation: Mujumdar, P.,Bua, S.,Supuran, C.T.,Peat, T.S.,Poulsen, S.A.; Synthesis, structure and bioactivity of primary sulfamate-containing natural products.; Bioorg. Med. Chem. Lett., 28:3009-3013, 2018; PubMed: 29685656; DOI: 10.1016/j.bmcl.2018.04.038

Experimental method

X-RAY DIFFRACTION (1.28 Å)