6C7R

BRD4 BD1 in complex with compound CF53

Summary for 6C7R

Entry DOI	10.2210/pdb6c7r/pdb
Descriptor	Bromodomain-containing protein 4, N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-2-methyl-9H-pyrimido[4,5-b]indol-4-amine (3 entities in total)
Functional Keywords	bromodomain, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15237.53
Authors	Meagher, J.L.,Stuckey, J.A. (deposition date: 2018-01-23, release date: 2018-08-01, Last modification date: 2023-10-04)
Primary citation	Zhao, Y.,Zhou, B.,Bai, L.,Liu, L.,Yang, C.Y.,Meagher, J.L.,Stuckey, J.A.,McEachern, D.,Przybranowski, S.,Wang, M.,Ran, X.,Aguilar, A.,Hu, Y.,Kampf, J.W.,Li, X.,Zhao, T.,Li, S.,Wen, B.,Sun, D.,Wang, S. Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. J. Med. Chem., 61:6110-6120, 2018 Cited by PubMed: 30015487 DOI: 10.1021/acs.jmedchem.8b00483 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation