6C6X

Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque.

Summary for 6C6X

• Entry DOI: 10.2210/pdb6c6x/pdb
• Descriptor: JC57-14 Heavy chain, JC57-14 Light chain (3 entities in total)
• Functional Keywords: antibody, neutralizing, vaccine, immune system
• Biological source: Macaca mulatta (Rhesus monkey); More
• Total number of polymer chains: 8
• Total formula weight: 189181.44

Authors

Joyce, M.G.,Mascola, J.R.,Graham, B.S.,Kwong, P.D. (deposition date: 2018-01-19, release date: 2018-02-28, Last modification date: 2023-10-04)

• Primary citation: Wang, L.,Shi, W.,Chappell, J.D.,Joyce, M.G.,Zhang, Y.,Kanekiyo, M.,Becker, M.M.,van Doremalen, N.,Fischer, R.,Wang, N.,Corbett, K.S.,Choe, M.,Mason, R.D.,Van Galen, J.G.,Zhou, T.,Saunders, K.O.,Tatti, K.M.,Haynes, L.M.,Kwong, P.D.,Modjarrad, K.,Kong, W.P.,McLellan, J.S.,Denison, M.R.,Munster, V.J.,Mascola, J.R.,Graham, B.S.; Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.; J. Virol., 92:-, 2018; PubMed: 29514901; DOI: 10.1128/JVI.02002-17

Experimental method

X-RAY DIFFRACTION (1.99 Å)