6C6X

Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque.

6C6X の概要

• エントリーDOI: 10.2210/pdb6c6x/pdb
• 分子名称: JC57-14 Heavy chain, JC57-14 Light chain (3 entities in total)
• 機能のキーワード: antibody, neutralizing, vaccine, immune system
• 由来する生物種: Macaca mulatta (Rhesus monkey); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 189181.44

構造登録者

Joyce, M.G.,Mascola, J.R.,Graham, B.S.,Kwong, P.D. (登録日: 2018-01-19, 公開日: 2018-02-28, 最終更新日: 2023-10-04)

• 主引用文献: Wang, L.,Shi, W.,Chappell, J.D.,Joyce, M.G.,Zhang, Y.,Kanekiyo, M.,Becker, M.M.,van Doremalen, N.,Fischer, R.,Wang, N.,Corbett, K.S.,Choe, M.,Mason, R.D.,Van Galen, J.G.,Zhou, T.,Saunders, K.O.,Tatti, K.M.,Haynes, L.M.,Kwong, P.D.,Modjarrad, K.,Kong, W.P.,McLellan, J.S.,Denison, M.R.,Munster, V.J.,Mascola, J.R.,Graham, B.S.; Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.; J. Virol., 92:-, 2018; PubMed: 29514901; DOI: 10.1128/JVI.02002-17

実験手法

X-RAY DIFFRACTION (1.99 Å)