6C6N

Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and Cmpd-4"

6C6N の概要

• エントリーDOI: 10.2210/pdb6c6n/pdb
• 関連するPDBエントリー: 6C6P 6C6R
• 分子名称: Squalene monooxygenase, GLYCEROL, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: cholesterol synthesis pathway, sqle, erg1, fad-dependent monooxygenase, squalene hydroxylase, squalene-2, 3-epoxidase, flavoprotein, oxidoreductase-oxidoreductase inhibitor complex, flavoprotein-inhibitor complex, flavoprotein/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 109122.65

構造登録者

Padyana, A.K.,Jin, L. (登録日: 2018-01-19, 公開日: 2019-01-16, 最終更新日: 2024-03-13)

• 主引用文献: Padyana, A.K.,Gross, S.,Jin, L.,Cianchetta, G.,Narayanaswamy, R.,Wang, F.,Wang, R.,Fang, C.,Lv, X.,Biller, S.A.,Dang, L.,Mahoney, C.E.,Nagaraja, N.,Pirman, D.,Sui, Z.,Popovici-Muller, J.,Smolen, G.A.; Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.; Nat Commun, 10:97-97, 2019; PubMed: 30626872; DOI: 10.1038/s41467-018-07928-x

実験手法

X-RAY DIFFRACTION (2.3 Å)