6C5N

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 1

6C5N の概要

• エントリーDOI: 10.2210/pdb6c5n/pdb
• 分子名称: Ketol-acid reductoisomerase (NADP(+)), NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: ketol-acid reductoisomerase, isomerase, inhibitor, oxidoreductase
• 由来する生物種: Staphylococcus aureus (strain bovine RF122 / ET3-1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77828.71

構造登録者

Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schembri, M.A.,McGeary, R.P. (登録日: 2018-01-16, 公開日: 2019-01-30, 最終更新日: 2023-10-04)

• 主引用文献: Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schembri, M.A.,McGeary, R.P.; Design, synthesis, in vitro activity and crystallisation of novel N-isopropyl-N-hydroxyoxamate derivatives as ketol-acid reductosiomerase (KARI) inhibitor; To Be Published,

実験手法

X-RAY DIFFRACTION (1.673 Å)