6C3E

CRYSTAL STRUCTURE OF RIP1 KINASE BOUND TO INHIBITOR

Summary for 6C3E

Entry DOI	10.2210/pdb6c3e/pdb
Descriptor	Receptor-interacting serine/threonine-protein kinase 1, 2-benzyl-5-nitro-1H-benzimidazole (3 entities in total)
Functional Keywords	human rip1 kinase, cell cycle, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q13546
Total number of polymer chains	2
Total formula weight	67698.04
Authors	Saikatendu, K.S.,Yoshikawa, M. (deposition date: 2018-01-09, release date: 2018-03-21, Last modification date: 2024-03-13)
Primary citation	Yoshikawa, M.,Saitoh, M.,Katoh, T.,Seki, T.,Bigi, S.V.,Shimizu, Y.,Ishii, T.,Okai, T.,Kuno, M.,Hattori, H.,Watanabe, E.,Saikatendu, K.S.,Zou, H.,Nakakariya, M.,Tatamiya, T.,Nakada, Y.,Yogo, T. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J. Med. Chem., 61:2384-2409, 2018 Cited by PubMed: 29485864 DOI: 10.1021/acs.jmedchem.7b01647 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation