6C1S
Phosphoinositide 3-Kinase gamma bound to an pyrrolopyridinone Inhibitor
6C1S の概要
エントリーDOI | 10.2210/pdb6c1s/pdb |
分子名称 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, {4-[2-(5,6-dimethoxypyridin-3-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1H-pyrazol-1-yl}acetonitrile, SULFATE ION, ... (4 entities in total) |
機能のキーワード | kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 112029.38 |
構造登録者 | |
主引用文献 | Come, J.H.,Collier, P.N.,Henderson, J.A.,Pierce, A.C.,Davies, R.J.,Le Tiran, A.,O'Dowd, H.,Bandarage, U.K.,Cao, J.,Deininger, D.,Grey, R.,Krueger, E.B.,Lowe, D.B.,Liang, J.,Liao, Y.,Messersmith, D.,Nanthakumar, S.,Sizensky, E.,Wang, J.,Xu, J.,Chin, E.Y.,Damagnez, V.,Doran, J.D.,Dworakowski, W.,Griffith, J.P.,Jacobs, M.D.,Khare-Pandit, S.,Mahajan, S.,Moody, C.S.,Aronov, A.M. Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). J. Med. Chem., 61:5245-5256, 2018 Cited by PubMed: 29847724DOI: 10.1021/acs.jmedchem.8b00085 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.31 Å) |
構造検証レポート
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